Telmisartan is a new lowering blood pressure drugs, it is a specific angiotensin Ⅱ receptor (AT Ⅰ type) antagonists. Telmisartan can alternate angiotensin Ⅱ receptor and AT Ⅰ receptor subtypes (known sites of action of angiotensin Ⅱ) high-affinity binding.
Telmisartan in AT Ⅰ receptor sites without any part of the agonist effects of telmisartan and AT Ⅰ receptor selectivity, the combined effect last long.
Telmisartan is without affinity on other receptors (including AT2 and other features less of the AT receptor). The function of other receptors remains to be seen, because telmisartan led to increased levels of angiotensin Ⅱ, which may cause over-stimulation effect of the receptor is also unknown. Telmisartan does not inhibit human plasma renin, does not block the ion channel.
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