Zidovudine (ZDV), also known as zidovudine (AZT), is an antiviral drug and a nucleoside reverse transcriptase inhibitor (NRTI). It is also the first drug for the treatment of HIV infection.
Zidovudine does not kill the virus, even we using a high doses, it can only slow the disease progression and viral replication. Under a Long-term teatment, zidovudine therapy to HIV reverse transcriptase resistance mutation occurred. To ease the drug resistance, zidovudine is generally recommended to uese with other mechanisms of antiviral drugs in combination, such as protease inhibitors or non-nucleoside reverse transcriptase inhibitors.
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