Bendamustine is a bifunctional alkylating agent-based, has effects of anti-tumor effect and killing the cells. In the early 1860s , it was fund by the ozegowski and his colleagues in Jena, Germany Society for Testing and development of micro-organisms. The product of the anti-tumor and kill the cells, the main mechanism for the role of DNA single-strand and double-cross-linked by alkylation, which disrupt the function of DNA and DNA synthesis, but also Bendamustine can make DNA and proteins which are between proteins and protein between cross-linking, and thus anti-tumor effect. This product alone or in combination with other anticancer drugs to treat various how Hodgkin disease, non-Hodgkin's lymphoma, plasma cell tumors (multiple myeloma), chronic lymphocytic leukemia (CLL), breast cancer and other malignancies.
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